{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01063 is a long non‐coding RNA that plays distinct roles in various cancer types. In melanoma, LINC01063 is upregulated and functions as an oncogene; it promotes cell proliferation, migration, invasion, and epithelial–mesenchymal transition by acting as a sponge for miR-5194, which in turn upregulates SOX12 expression. Its increased expression correlates with advanced stage and metastasis in melanoma patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond melanoma, LINC01063 has been incorporated in several prognostic signatures across different tumors. In colon adenocarcinoma and colon cancer, it is part of ferroptosis-related and autophagy-related lncRNA panels that predict patient outcome, tumor mutation burden, immune characteristics, and even drug sensitivity to therapies such as sorafenib."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In hepatocellular carcinoma, LINC01063 is included within risk models based on ferroptosis- and autophagy-related lncRNAs that have prognostic value for overall survival and potential for guiding individualized treatments, including the prediction of responses to immunotherapy and targeted therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, studies in breast cancer have demonstrated that LINC01063 expression is significantly decreased in tumor tissues compared to non-cancerous counterparts, suggesting it may serve as a tissue marker with potential relevance to tumor immunity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, the function of LINC01063 appears to be context dependent. It acts as an oncogenic driver in melanoma by modulating microRNA activity and downstream gene expression, whereas in colon cancer, hepatocellular carcinoma, and colorectal cancer it contributes to multigene prognostic signatures linked to ferroptosis and autophagy pathways. Its downregulation in breast cancer highlights the complexity of its regulatory roles across different tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiangmei Xu, Rongying Ou, Gang Nie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01063 functions as an oncogene in melanoma through regulation of miR-5194-mediated SOX12 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Melanoma Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CMR.0000000000000803"}], "href": "https://doi.org/10.1097/CMR.0000000000000803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35256570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35256570"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuting Qiu, Haobo Li, Qian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ferroptosis-Related Long Noncoding RNAs as Prognostic Marker for Colon Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Appl Bionics Biomech (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/5220368"}], "href": "https://doi.org/10.1155/2022/5220368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35432591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35432591"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenzheng Chen, Yafei Chen, Li Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of Immune Infiltrates of Ferroptosis-Related Long Noncoding RNA and Prediction of Colon Cancer Patient Prognoses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/9480628"}], "href": "https://doi.org/10.1155/2022/9480628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35265722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35265722"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Weige Zhou, Shijing Zhang, Hui-Biao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/9807918"}], "href": "https://doi.org/10.1155/2020/9807918"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32964050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32964050"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ze Zhang, Wenwen Zhang, Yafei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction and Validation of a Ferroptosis-Related lncRNA Signature as a Novel Biomarker for Prognosis, Immunotherapy and Targeted Therapy in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2022.792676"}], "href": "https://doi.org/10.3389/fcell.2022.792676"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35295858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35295858"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaoyu Deng, Qinghua Bi, Shihan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a Five-Autophagy-Related-lncRNA Signature as a Novel Prognostic Biomarker for Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Mol Biosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fmolb.2020.611626"}], "href": "https://doi.org/10.3389/fmolb.2020.611626"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33505990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33505990"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Soudeh Ghafouri-Fard, Mohammad Asadi, Behnoush Sohrabi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of a panel of immune-related lncRNAs in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2021.153534"}], "href": "https://doi.org/10.1016/j.prp.2021.153534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34175685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34175685"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Lin Cheng, Tong Han, Zheyu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Validation of Six Autophagy-related Long Non-coding RNAs as Prognostic Signature in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijms.49449"}], "href": "https://doi.org/10.7150/ijms.49449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33390777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33390777"}]}]}]}