{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01068 is a long non‐coding RNA whose potential roles seem to be context‐dependent. In a study of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), comprehensive transcriptome analyses performed before and after exercise revealed only a handful of differentially expressed transcripts—with no clear evidence of immune signaling or other transcriptional changes, suggesting that LINC01068 (if present in the dataset) is not markedly involved in the exercise‐induced pathophysiology or post‐exertional malaise in ME/CFS patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in the context of esophageal squamous cell carcinoma (ESCC), LINC01068 was identified as one of several prognostic long non‐coding RNAs incorporated into a multi‐RNA expression model. Here, its co‐expression with mRNAs in a regulatory network implies that it may contribute to pathways influencing tumor progression and thereby serve as a potential prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings suggest that while LINC01068 might not play a significant transcriptional role in ME/CFS, it could be functionally relevant in the molecular mechanisms underlying ESCC prognosis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jerome Bouquet, Tony Li, Jennifer L Gardy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0212193"}], "href": "https://doi.org/10.1371/journal.pone.0212193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30897114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30897114"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaobo Shi, You Li, Yuchen Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide analysis of lncRNAs, miRNAs, and mRNAs forming a prognostic scoring system in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.8368"}], "href": "https://doi.org/10.7717/peerj.8368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32095316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32095316"}]}]}]}