{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01080, a long intergenic noncoding RNA, appears to be involved in modulating neurodevelopmental processes and influencing neurocognitive phenotypes. Evidence from studies in schizophrenia revealed that while the SNP rs7990916 within LINC01080 does not significantly alter disease risk, it is associated with an earlier age of onset and impaired cognitive functions—specifically deficits in executive planning and processing speed—in affected individuals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, investigation of the same genetic variant in the context of Alzheimer’s disease did not support an association with the risk of sporadic Alzheimer’s disease or amnestic mild cognitive impairment in a Han Chinese population."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " These findings suggest that LINC01080’s functional role may be more pertinent to the modulation of neurocognitive performance and clinical heterogeneity in psychiatric disorders such as schizophrenia rather than serving as a universal risk factor across neurodegenerative diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi Qi, Yaxue Wei, Fengyan Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Psychiatry (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12888-021-03623-2"}], "href": "https://doi.org/10.1186/s12888-021-03623-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34879837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34879837"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xin Luo, Jianzhong Zhu, Zaohuo Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of association of a genetic variant in the long intergenic noncoding RNA (linc01080) with Alzheimer's disease and amnestic mild cognitive impairment in Han Chinese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/00207454.2014.944616"}], "href": "https://doi.org/10.3109/00207454.2014.944616"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25019275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25019275"}]}]}]}