{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01082 is a long non‐coding RNA that appears to participate in both developmental lung disorders and cancer progression through regulatory and epigenetic mechanisms. In the context of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), genomic deletions and differential DNA methylation mapping to the FOXF1 upstream enhancer region—including the locus containing LINC01082—suggest that its disruption may contribute to aberrant FOXF1 expression via imprinting‐related mechanisms (1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cancer, LINC01082 is frequently downregulated. In colon cancer, functional studies have demonstrated that restoration of LINC01082 expression suppresses cell proliferation, migration, and invasion, consistent with a tumor‐suppressive role (2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, analyses in prostate and gastric cancers have identified LINC01082 as a potential prognostic biomarker, with overexpression correlating with reduced invasiveness and decreased immunomodulatory factors such as PD‑L1 (5."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, its inclusion in metabolism‐ and immune‐related lncRNA signatures in colorectal cancer further supports its emerging relevance in tumor biology (7). Collectively, these findings indicate that LINC01082 acts as an important regulatory molecule whose loss or reduction may contribute to both developmental lung abnormalities, via dysregulation of critical transcriptional networks, and to tumor progression by failing to control cell growth and invasion.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n "}, {"type": "b", "children": [{"type": "t", "text": "Citations:"}]}, {"type": "t", "text": "\n <br>\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "&nbsp;\n (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "&nbsp;\n (3)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "&nbsp;\n (4)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "&nbsp;\n (5)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "&nbsp;\n (6)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "&nbsp;\n (7)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "&nbsp;\n (8)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sahar V Mozaffari, Jeanne M DeCara, Sanjiv J Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-018-0267-4"}], "href": "https://doi.org/10.1038/s42003-018-0267-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30675526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30675526"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Katharina V Schulze, Przemyslaw Szafranski, Harry Lesmana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel parent-of-origin-specific differentially methylated loci on chromosome 16."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-019-0655-8"}], "href": "https://doi.org/10.1186/s13148-019-0655-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30961659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30961659"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei Huang, Zhen Liu, Yu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of long noncoding RNAs biomarkers for diagnosis and prognosis in patients with colon adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27697"}], "href": "https://doi.org/10.1002/jcb.27697"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30269368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30269368"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jun Wang, Beidi Wang, Biting Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel immune-related lncRNA pair signature for prognostic prediction and immune response evaluation in gastric cancer: a bioinformatics and biological validation study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-022-02493-2"}], "href": "https://doi.org/10.1186/s12935-022-02493-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35144613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35144613"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Przemyslaw Szafranski, Tomasz Gambin, Avinash V Dharmadhikari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-016-1655-9"}], "href": "https://doi.org/10.1007/s00439-016-1655-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27071622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27071622"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wei Xiong, Jiyong Qin, Xinyi Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression LINC01082 suppresses the proliferation, migration and invasion of colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-019-03607-7"}], "href": "https://doi.org/10.1007/s11010-019-03607-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31432387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31432387"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tengfei Zhang, Yaxuan Wang, Yiming Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Novel Diagnostic Biomarkers in Prostate Adenocarcinoma Based on the Stromal-Immune Score and Analysis of the WGCNA and ceRNA Network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/1909196"}], "href": "https://doi.org/10.1155/2022/1909196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35075375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35075375"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yongqu Lu, Wendong Wang, Zhenzhen Liu, et al. 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