{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01087 has emerged as a multifunctional long non‐coding RNA involved in the regulation of tumor biology and other disease processes. In breast cancer, its expression appears to be subtype‐dependent; LINC01087 is reported to be downregulated in triple‐negative tumors yet upregulated in luminal tumors, with its deregulation serving not only as a diagnostic marker to distinguish these subtypes but also as a prognostic indicator, where altered levels correlate with patient survival outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In mechanistic studies, LINC01087 acts as a competing endogenous RNA by sponging various microRNAs – for example, miR-335-5p in breast cancer to modulate ROCK1 expression, and miR-1277-5p in glioma to regulate ACER3 levels – thereby influencing key cellular processes such as cell survival, proliferation, invasion, migration, and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Similar ceRNA mechanisms have been observed in thyroid cancer, where LINC01087 sponges miR-135a-5p to affect PPM1E expression and promote malignant behavior"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while it has also been incorporated into biomarker panels for prognosis prediction in esophageal carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and identified as a candidate regulator in high-throughput deletion screening of cancer growth modulators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, LINC01087 is suggested to be part of an m6A-related lncRNA network with potential relevance to gestational diabetes mellitus."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Altogether, these studies underscore the context-dependent oncogenic or tumor-suppressive functions of LINC01087, highlighting its value as a diagnostic, prognostic, and potentially therapeutic biomarker in diverse disease settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fatima Domenica Elisa De Palma, Valentina Del Monaco, Jonathan G Pol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The abundance of the long intergenic non-coding RNA 01087 differentiates between luminal and triple-negative breast cancers and predicts patient outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacol Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.phrs.2020.105249"}], "href": "https://doi.org/10.1016/j.phrs.2020.105249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33068730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33068730"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ji-Kai She, Dan-Ni Fu, Dong Zhen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01087 is Highly Expressed in Breast Cancer and Regulates the Malignant Behavior of Cancer Cells Through miR-335-5p/Rock1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S255994"}], "href": "https://doi.org/10.2147/OTT.S255994"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33061456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33061456"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rashmi Tripathi, Imlimaong Aier, Pavan Chakraborty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unravelling the role of long non-coding RNA - "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC01087"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Noncoding RNA Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ncrna.2019.12.002"}], "href": "https://doi.org/10.1016/j.ncrna.2019.12.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31989062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31989062"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Leimarembi Devi Naorem, Vigneshwar Suriya Prakash, Mathavan Muthaiyan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of dysregulated lncRNAs and their competing endogenous RNA network in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Macromol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijbiomac.2019.12.196"}], "href": "https://doi.org/10.1016/j.ijbiomac.2019.12.196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31883894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31883894"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wangsheng Chen, Fei Wang, Jianhua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01087 indicates a poor prognosis of glioma patients with preoperative MRI."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Funct Integr Genomics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10142-021-00812-w"}], "href": "https://doi.org/10.1007/s10142-021-00812-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34817752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34817752"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yao-Hui Tian, Lin-Wei Jia, Zhi-Feng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01087 inhibits glioma cell proliferation and migration, and increases cell apoptosis via miR-384/Bcl-2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203478"}], "href": "https://doi.org/10.18632/aging.203478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34459789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34459789"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ying Yin, Jianhao Huang, Hongyan Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01087 Promotes the Proliferation, Migration, and Invasion of Thyroid Cancer Cells by Upregulating PPM1E."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/7787378"}], "href": "https://doi.org/10.1155/2022/7787378"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35368894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35368894"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jin Zhang, Fei Xiao, Guangliang Qiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel lncRNA Panel as for Prognosis in Esophageal Squamous Cell Carcinoma Based on ceRNA Network Mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/8020879"}], "href": "https://doi.org/10.1155/2021/8020879"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34603485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34603485"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shiyou Zhu, Wei Li, Jingze Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Biotechnol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nbt.3715"}], "href": "https://doi.org/10.1038/nbt.3715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27798563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27798563"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiao-Xiao Li, Li-Juan Wang, Jie Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Long Noncoding RNAs as Predictors of Survival in Triple-Negative Breast Cancer Based on Network Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8970340"}], "href": "https://doi.org/10.1155/2020/8970340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32190687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32190687"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Runyu Du, Yu Bai, Ling Li "}, {"type": "b", "children": [{"type": "t", "text": "Biological networks in gestational diabetes mellitus: insights into the mechanism of crosstalk between long non-coding RNA and N"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-methyladenine modification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Pregnancy Childbirth (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12884-022-04716-w"}], "href": "https://doi.org/10.1186/s12884-022-04716-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35505296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35505296"}]}]}]}