{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01088 is a long intergenic non‐coding RNA that has been reported to exert context‐dependent roles in human diseases. In epithelial ovarian cancer, for example, two independent studies show that LINC01088 is down‐regulated compared to normal tissues, and its reduced expression is associated with advanced stage, higher grade, distant metastasis, and poorer overall survival. Mechanistically, LINC01088 functions as a tumor suppressor by inhibiting cell proliferation through modulation of the miR‑24‑1‑5p/PAK4 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Conversely, in several other cancers LINC01088 appears to have oncogenic functions. In glioma, LINC01088 is up‐regulated and promotes cell proliferation and invasion by physically interacting with SNRPA and transcriptionally regulating its expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In colorectal cancer, elevated LINC01088 facilitates tumor progression and immune escape by acting as a sponge for miR‑548b‑5p and miR‑548c‑5p, thereby enhancing the expression of G3BP1 and PD‑L1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In non‑small cell lung cancer, high LINC01088 expression promotes cell cycle progression by directly binding EZH2 to suppress p21 expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and in lung squamous cell carcinoma it has been linked with a poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its roles in tumor biology, LINC01088 has been implicated in non‐cancerous conditions. In trophoblast cells from patients with recurrent pregnancy loss, increased LINC01088 expression suppresses proliferation, migration, and invasion while promoting apoptosis via alterations in nitric oxide production and activation of JNK/p38 MAPK signaling pathways, suggesting a contributory role in the pathogenesis of this disorder."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, LINC01088 has also been identified as a potential diagnostic marker in alcoholic liver disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, LINC01088 displays diverse, tissue‑specific regulatory functions, acting either as a tumor suppressor or as an oncogene depending on the cellular context. These findings underscore its promise both as a therapeutic target and as a biomarker in a variety of human diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Weijiang Zhang, Jing Fei, Shuqian Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01088 inhibits tumorigenesis of ovarian epithelial cells by targeting miR-24-1-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-21164-9"}], "href": "https://doi.org/10.1038/s41598-018-21164-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29440672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29440672"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "H Ai, W Xie, A-H Xiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The down-regulation of long non-coding RNA LINC01088 is associated with the poor prognosis of epithelial ovarian cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201809_15910"}], "href": "https://doi.org/10.26355/eurrev_201809_15910"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30280763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30280763"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tao Peng, Dong-Liang Chen, Shi-Lan Chen "}, {"type": "b", "children": [{"type": "t", "text": "LINC01088 promotes the growth and invasion of glioma cells through regulating small nuclear ribonucleoprotein polypeptide A transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2051786"}], "href": "https://doi.org/10.1080/21655979.2022.2051786"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35392763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35392763"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chenmeng Li, Bei Pan, Xuhong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated LINC01088 facilitates malignant phenotypes and immune escape of colorectal cancer by regulating microRNAs/G3BP1/PD-L1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-022-03981-8"}], "href": "https://doi.org/10.1007/s00432-022-03981-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35357586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35357586"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jie-Qiong Liu, Yu-Hua Feng, Shan Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "linc01088 promotes cell proliferation by scaffolding EZH2 and repressing p21 in human non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2019.117134"}], "href": "https://doi.org/10.1016/j.lfs.2019.117134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31811854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31811854"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jieqiong Liu, Yali Yao, Zheyu Hu, et al. 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