{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐protein coding RNA 01089 (LINC01089), also known as LIMT (LncRNA Inhibiting Metastasis), has emerged as a tumor‐suppressive long noncoding RNA in multiple human cancers. In breast, cervical, lung, gastric, colorectal, and hepatocellular carcinomas, LINC01089 is frequently down‐regulated, and its low expression correlates with advanced disease features such as larger tumor size, lymph node metastasis, poor overall survival, and even chemoresistance (for example, sorafenib resistance in hepatocellular carcinoma)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, LINC01089 functions as a competitive endogenous RNA (ceRNA) by sponging various oncogenic microRNAs – including miR‑27a‑3p, miR‑27b‑3p, miR‑301b‑3p, miR‑543, miR‑152‑3p, miR‑3187‑3p, and miR‑145‑5p – which leads to the derepression and consequent up‐regulation of tumor suppressor genes such as BTG2, HPGD, HOXA10, TET1, PTEN, SFRP1, and STARD13. This ceRNA network results in the inhibition of cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) in various cancer cell types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, the down‐regulation of LINC01089 appears to remove a critical brake on tumor progression and metastasis, making it a promising prognostic biomarker and a potential therapeutic target across several cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Aldema Sas-Chen, Miriam R Aure, Limor Leibovich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201606198"}], "href": "https://doi.org/10.15252/emmm.201606198"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27485121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27485121"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shuoxi Li, Yu Han, Xuesong Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01089 inhibits the progression of cervical cancer via inhibiting miR-27a-3p and increasing BTG2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3280"}], "href": "https://doi.org/10.1002/jgm.3280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33025678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33025678"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rusong Yang, Zhengcheng Liu, Hui Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01089, suppressed by YY1, inhibits lung cancer progression by targeting miR-301b-3p/HPDG axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10565-021-09643-8"}], "href": "https://doi.org/10.1007/s10565-021-09643-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34561789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34561789"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jing Sun, Xiaoxiao Zheng, Baoming Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LIMT (LINC01089) contributes to sorafenib chemoresistance via regulation of miR-665 and epithelial to mesenchymal transition in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3724/abbs.2021019"}], "href": "https://doi.org/10.3724/abbs.2021019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35130616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35130616"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Feng Yang, Xiaoting Chen, Xiyao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Intergenic Non-Protein Coding RNA 1089 Suppresses Cell Proliferation and Metastasis in Gastric Cancer by Regulating miRNA-27a-3p/Epithelial-Mesenchymal Transition (EMT) Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S254064"}], "href": "https://doi.org/10.2147/CMAR.S254064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32753971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32753971"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xufeng Guo, Ming Li "}, {"type": "b", "children": [{"type": "t", "text": "LINC01089 is a tumor-suppressive lncRNA in gastric cancer and it regulates miR-27a-3p/TET1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-01561-9"}], "href": "https://doi.org/10.1186/s12935-020-01561-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33088215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33088215"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Youwen Xu, Ling Lin, Dongqing Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA-LINC01089 inhibits lung adenocarcinoma cell proliferation and promotes apoptosis via sponging miR-543."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tissue Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tice.2021.101535"}], "href": "https://doi.org/10.1016/j.tice.2021.101535"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33892399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33892399"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ye Qian, Yan Zhang, Haoming Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01089 suppresses lung adenocarcinoma cell proliferation and migration via miR-301b-3p/STARD13 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Pulm Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12890-021-01568-6"}], "href": "https://doi.org/10.1186/s12890-021-01568-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34281560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34281560"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Huixian Zhang, Hao Zhang, Xingya Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01089 functions as a ceRNA for miR-152-3p to inhibit non-small lung cancer progression through regulating PTEN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-021-01846-7"}], "href": "https://doi.org/10.1186/s12935-021-01846-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33653358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33653358"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xingkai Li, Fang Lv, Fang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01089 Inhibits Tumorigenesis and Epithelial-Mesenchymal Transition of Non-small Cell Lung Cancer "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " the miR-27a/SFRP1/Wnt/β-catenin Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.532581"}], "href": "https://doi.org/10.3389/fonc.2020.532581"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33282723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33282723"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dongdong Zhang, Xingdong Cai, Songwang Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Intergenic Non-Protein Coding RNA 01089 Weakens Tumor Proliferation, Migration, and Invasion by Sponging miR-3187-3p in Non-Small Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S258532"}], "href": "https://doi.org/10.2147/CMAR.S258532"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33269007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33269007"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ming Li, Xufeng Guo "}, {"type": "b", "children": [{"type": "t", "text": "LINC01089 Blocks the Proliferation and Metastasis of Colorectal Cancer Cells via Regulating miR-27b-3p/HOXA10 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S256148"}], "href": "https://doi.org/10.2147/OTT.S256148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32884303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32884303"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hongfan Yuan, Yi Qin, Beilei Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01089 predicts clinical prognosis and inhibits cell proliferation and invasion through the Wnt/β-catenin signaling pathway in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S208830"}], "href": "https://doi.org/10.2147/OTT.S208830"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31417284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31417284"}]}]}]}