{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have advanced our understanding of how genetic and epigenetic factors contribute to complex disorders, including posttraumatic stress disorder (PTSD) and lung adenocarcinoma (LUAD)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " While the first three studies focus on the interplay between genetic predisposition, epigenetic regulation, and neural circuit structure in determining susceptibility and resilience to PTSD, a separate investigation has delineated an eight–long non‐coding RNA (lncRNA) signature that is prognostically significant in LUAD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Within this prognostic panel, LINC01090 has been identified as a key lncRNA biomarker. Its expression is associated with LUAD patient survival outcomes and correlates with alterations in tumor immune infiltration, including the abundance of multiple immune cell types and the modulation of major histocompatibility complex (MHC) molecule expression. Moreover, LINC01090 is integrated into a competing endogenous RNA (ceRNA) network that may reveal novel mechanistic insights and anti-cancer therapeutic targets. Collectively, these findings underscore the multifaceted roles of lncRNAs—exemplified by LINC01090—in cancer biology and their emerging utility in precision prognostic assessment.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lauren A M Lebois, Jonathan D Wolff, Kerry J Ressler "}, {"type": "b", "children": [{"type": "t", "text": "Neuroimaging genetic approaches to Posttraumatic Stress Disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Neurol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.expneurol.2016.04.019"}], "href": "https://doi.org/10.1016/j.expneurol.2016.04.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27109180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27109180"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nikolaos P Daskalakis, Chuda M Rijal, Christopher King, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recent Genetics and Epigenetics Approaches to PTSD."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Psychiatry Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11920-018-0898-7"}], "href": "https://doi.org/10.1007/s11920-018-0898-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29623448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29623448"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hunter Howie, Chuda M Rijal, Kerry J Ressler "}, {"type": "b", "children": [{"type": "t", "text": "A review of epigenetic contributions to post-traumatic stress disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dialogues Clin Neurosci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31887/DCNS.2019.21.4/kressler"}], "href": "https://doi.org/10.31887/DCNS.2019.21.4/kressler"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31949409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31949409"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yan Chen, Xiuxiu Zhang, Jinze Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immune-related eight-lncRNA signature for improving prognosis prediction of lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24018"}], "href": "https://doi.org/10.1002/jcla.24018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34550610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34550610"}]}]}]}