{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In prostate cancer, LINC01091 appears to be implicated as an epigenetic indicator whose differential methylation status distinguishes tumor tissue from normal tissue. Analysis of genome‐wide DNA methylation patterns involving hundreds of thousands of CpG sites demonstrated that, among a panel of five informative CpG loci, alterations at the LINC01091 locus contributed to a highly accurate mathematical model for prostate cancer diagnosis. Although the precise molecular function of LINC01091 remains to be fully characterized, its inclusion among the key methylation markers suggests that it may play a role in the regulatory networks underlying aberrant gene expression associated with prostate tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jason B Nikas, Emily G Nikas "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide DNA Methylation Model for the Diagnosis of Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "ACS Omega (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acsomega.9b01613"}], "href": "https://doi.org/10.1021/acsomega.9b01613"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31552329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31552329"}]}]}]}