{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01093 is a liver‐specific long noncoding RNA that is consistently downregulated in malignant liver conditions, including hepatocellular carcinoma (HCC), HBV‐associated HCC, alcoholic hepatitis, and liver fibrosis. In HCC, reduced LINC01093 expression is correlated with advanced TNM stage, the presence of cancer embolus, and poor prognosis, whereas its overexpression suppresses tumor cell proliferation and metastasis. Mechanistic studies show that LINC01093 can bind to proteins such as insulin‐like growth factor 2 mRNA‑binding protein 1, thereby interfering with the stabilization of oncogenic transcripts like GLI1 and ultimately dampening downstream pathways that promote hepatocarcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, LINC01093 acts as a competing endogenous RNA, modulating signaling cascades such as NF‑κB via a miRNA–mediated axis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", which further supports its tumor‑suppressive role. In models of liver fibrosis and alcoholic hepatitis, downregulation of LINC01093 contributes to increased hepatocyte apoptosis through enhanced degradation and ubiquitination of SIRT1 as well as activation of the ICAM‑1–mediated NF‑κB pathway; conversely, restoring LINC01093 expression improves cell viability and ameliorates fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, LINC01093 is markedly decreased in malignant liver tumors relative to benign lesions, highlighting its diagnostic potential, and its expression levels have been integrated into prognostic models for HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Finally, in HBV‑associated HCC, LINC01093 has also emerged as a promising biomarker with significant diagnostic and prognostic value"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while elevated LINC01093 expression is associated with improved clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings underline an important tumor suppressor and hepatoprotective role for LINC01093 in liver pathophysiology, making it a promising candidate for early diagnosis, prognosis evaluation, and targeted therapy in liver diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jia He, Qiaozhu Zuo, Bo Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2019.02.033"}], "href": "https://doi.org/10.1016/j.canlet.2019.02.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30790682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30790682"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yahui Zheng, Kangkang Yu, Chong Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated bioinformatics analysis reveals role of the LINC01093/miR-96-5p/ZFAND5/NF-κB signaling axis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2019.8046"}], "href": "https://doi.org/10.3892/etm.2019.8046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31641376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31641376"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yinhe Tang, Naijing Ma, Hao Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvaa013"}], "href": "https://doi.org/10.1093/jb/mvaa013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32044992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32044992"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xu Shi, Xiaoming Jiang, Baoshan Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01093 Upregulation Protects against Alcoholic Hepatitis through Inhibition of NF-κB Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2019.06.018"}], "href": "https://doi.org/10.1016/j.omtn.2019.06.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31450097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31450097"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wenhui Yang, Yuan Li, Xia Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide analysis of long noncoding RNA and mRNA co-expression profile in intrahepatic cholangiocarcinoma tissue by RNA sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15721"}], "href": "https://doi.org/10.18632/oncotarget.15721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28427159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28427159"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Olga Y Burenina, Natalia L Lazarevich, Inna F Kustova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Panel of potential lncRNA biomarkers can distinguish various types of liver malignant and benign tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-020-03378-5"}], "href": "https://doi.org/10.1007/s00432-020-03378-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32918630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32918630"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yonghua Mou, Dongguo Wang, Renwei Xing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of long noncoding RNAs biomarkers in patients with hepatitis B virus-associated hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-181424"}], "href": "https://doi.org/10.3233/CBM-181424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29991128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29991128"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Meiyu Dai, Siyuan Chen, Xiaomou Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnosis, prognosis and bioinformatics analysis of lncRNAs in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.21329"}], "href": "https://doi.org/10.18632/oncotarget.21329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29221168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29221168"}]}]}]}