{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐coding RNA LINC01094 has emerged as a key regulatory molecule in several pathologic conditions, most notably in a variety of cancers. In malignancies such as clear cell renal cell carcinoma, breast cancer, glioma/glioblastoma, colorectal cancer, ovarian cancer, pancreatic cancer, and gastric cancer, LINC01094 is frequently overexpressed and functions as a potent oncogene by promoting cell proliferation, migration, invasion, and even radioresistance. Mechanistically, LINC01094 predominantly acts as a competing endogenous RNA that “sponges” a range of tumor‐suppressive microRNAs including miR‐224‑5p, miR‑340‑5p, miR‑577, miR‑330‑3p, and miR‑1266‑5p among others. By binding these microRNAs, it de‐represses downstream targets—such as CHSY1, E2F3, β‑catenin pathway effectors, LIN28B, BDNF, CHEK2/FOXM1, MSI1, and DCTN4—that are critical for driving tumor growth, metastasis, epithelial–mesenchymal transition, and therapeutic resistance"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its well‐characterized role in oncogenesis, LINC01094 has also been implicated in other pathological states. For instance, it appears as a critical component within a competing endogenous RNA network in schizophrenia, suggesting a role in neuropsychiatric regulation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ", and its altered expression has been associated with postmenopausal osteoporosis, providing insights into its potential as a prognostic biomarker in non‐malignant disease settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore that LINC01094 modulates diverse oncogenic processes by sponging key microRNAs and consequently upregulating a spectrum of oncogenes and signaling pathways. This multifaceted regulatory role not only enhances tumor progression and metastasis but also impacts therapeutic responses, thereby positioning LINC01094 as a promising biomarker and potential therapeutic target for multiple disease entities.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yufeng Jiang, Haimin Zhang, Wei Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LINC01094 triggers radio-resistance in clear cell renal cell carcinoma via miR-577/CHEK2/FOXM1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-01306-8"}], "href": "https://doi.org/10.1186/s12935-020-01306-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32595418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32595418"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xia Wu, Cui Kong, Yilei Wu "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-protein coding RNA 1094 (LINC01094) promotes the progression of breast cancer (BC) by regulating the microRNA-340-5p (miR-340-5p)/E2F transcription factor 3 (E2F3) axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1993715"}], "href": "https://doi.org/10.1080/21655979.2021.1993715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34657558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34657558"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Guangliang Zhang, Yingjie Gao, Zhen Yu, et al. 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