{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent genome‐wide association studies have implicated the long non‐coding RNA "}, {"type": "b", "children": [{"type": "t", "text": "LINC01098"}]}, {"type": "t", "text": " in the genetic architecture of distinct human conditions. In one study investigating selective immunoglobulin A deficiency (IgAD) in Europeans, variants mapping to LINC01098 were identified as novel significant loci, suggesting that this non‐coding RNA may influence pathways involved in immune regulation and IgA production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate genome‐wide investigation of lifelong premature ejaculation (LPE) in Chinese Han men, polymorphisms within LINC01098 emerged among other genetic variants associated with LPE risk, thereby proposing a potential role for LINC01098 in neurophysiological or hormonal pathways affecting sexual function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although the precise mechanisms remain to be elucidated, the association of LINC01098 with both immunological and neuroendocrine traits points to its multifaceted regulatory capabilities. Further research is warranted to clarify its functional impact and the biological pathways through which it contributes to these diverse disease phenotypes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Paola G Bronson, Diana Chang, Tushar Bhangale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3675"}], "href": "https://doi.org/10.1038/ng.3675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27723758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27723758"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fei Wang, Defan Luo, Jianxiang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Association Analysis to Search for New Loci Associated with Lifelong Premature Ejaculation Risk in Chinese Male Han Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Mens Health (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5534/wjmh.210084"}], "href": "https://doi.org/10.5534/wjmh.210084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35021295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35021295"}]}]}]}