{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent data indicate that LINC01101, a long intergenic non‐coding RNA, may be involved in modulating gene expression in the context of HPV‐induced cervical pathogenesis. In HPV18 E7‐silenced HeLa cells, significant downregulation of LINC01101 was observed, and reduced transcript levels were further confirmed in hrHPV‐positive cervical lesions and cancers. This pattern of decreased expression suggests that LINC01101 could act as a regulatory molecule in cervical neoplasia, potentially contributing to tumor suppression mechanisms that are compromised by HPV infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although investigations in other biomedical contexts, such as breast cancer risk by single nucleotide polymorphisms (SNPs) and chromosomal translocations associated with limb malformations, have provided insights into diverse genetic and regulatory mechanisms"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", none of these studies reported a role for LINC01101. In contrast, the findings related to HPV‐associated cervical disease specifically emphasize the significance of LINC01101 downregulation as a potential marker or mediator in the progression of HPV‐induced oncogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Iulia Virginia Iancu, Gabriela Anton, Anca Botezatu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01101 and LINC00277 expression levels as novel factors in HPV-induced cervical neoplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13288"}], "href": "https://doi.org/10.1111/jcmm.13288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28767188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28767188"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xu Li, Wenjing Zou, Ming Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of multiple genetic variants with breast cancer susceptibility in the Han Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13402"}], "href": "https://doi.org/10.18632/oncotarget.13402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27863437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27863437"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Christian Babbs, Raoul Heller, David B Everman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A new locus for split hand/foot malformation with long bone deficiency (SHFLD) at 2q14.2 identified from a chromosome translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-007-0390-7"}], "href": "https://doi.org/10.1007/s00439-007-0390-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17569090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17569090"}]}]}]}