{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted that aberrant overexpression of the long non‐coding RNA LINC01106 is closely associated with tumor progression and unfavorable prognosis in multiple cancers. In gastric cancer, for example, LINC01106 is markedly up‐regulated and functions as a competing endogenous RNA (ceRNA) by sponging miR‑34a‑5p, which consequently de‐represses the oncogene MYCN. This interaction enhances cell viability, invasion, and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colorectal cancer, elevated LINC01106 not only promotes cell proliferation and suppresses apoptosis—likely via modulation of the STAT3/Bcl‑2 signaling pathway—but also augments cancer stem‐like characteristics. One study showed that cytoplasmic LINC01106 sequesters miR‑449b‑5p to upregulate Gli4, while nuclear LINC01106 recruits transcriptional regulators to stimulate Gli1 and Gli2 expression; notably, Gli2 can further activate LINC01106 expression, establishing a positive feedback loop that facilitates tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional data in the context of inflammatory bowel disease–related colorectal cancer identified LINC01106 as a component of ceRNA networks linked to immune and inflammatory responses, with its expression significantly correlating with clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In endometrial cancer, overexpression of LINC01106 has been demonstrated to promote proliferation, migration, and invasion by sponging miR‑449a, thereby relieving repression of its target MET. Knockdown of LINC01106 in both in vitro and in vivo models suppressed these oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in gastric adenocarcinoma, LINC01106 has emerged as a crucial prognostic biomarker within a broader ceRNA network, further emphasizing its importance in cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n It is noteworthy that a related long non‐coding RNA, LINC01116, has been described in bladder cancer where it promotes tumor progression by regulating target genes such as ELK3 and HOXD8 through miRNA sponging and mRNA stabilization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Although LINC01116 and LINC01106 are distinct transcripts, these findings collectively underscore the versatile and oncogenic functions of lncRNAs in modulating gene expression networks across different malignancies.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, LINC01106 acts as an oncogenic regulator by functioning as a ceRNA that modulates multiple miRNA–mRNA axes—including miR‑34a‑5p/MYCN, miR‑449a/MET, miR‑449b‑5p/Gli4, and the STAT3/Bcl‑2 pathway—and by interacting with transcriptional regulators to drive proliferation, migration, invasion, and stem-like phenotypes in several human cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sen Hong, Qiuxia Li, Ying Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of Long Non-coding RNA LINC01106 Represses Malignant Behaviors of Gastric Cancer Cells by Targeting miR-34a-5p/MYCN Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biotechnol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12033-021-00402-y"}], "href": "https://doi.org/10.1007/s12033-021-00402-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34550549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34550549"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuchen Gu, Yingying Huang, Yiming Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Long non-coding RNA LINC01106 regulates colorectal cancer cell proliferation and apoptosis through the STAT3 pathway]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2020.09.06"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2020.09.06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32990221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32990221"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kun Guo, Wenbin Gong, Qin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01106 drives colorectal cancer growth and stemness through a positive feedback loop to regulate the Gli family factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-03026-3"}], "href": "https://doi.org/10.1038/s41419-020-03026-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33067422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33067422"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Fangfang Sun, Weiwei Liang, Kejun Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Profiling the lncRNA-miRNA-mRNA ceRNA network to reveal potential crosstalk between inflammatory bowel disease and colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.7451"}], "href": "https://doi.org/10.7717/peerj.7451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31523496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31523496"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xihuan Gao, Liming Yu, Jingjing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of Long Non-Coding RNA LINC01106 Suppresses the Proliferation, Migration and Invasion of Endometrial Cancer Cells Through Regulating the miR-449a/MET Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S264642"}], "href": "https://doi.org/10.2147/OTT.S264642"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33061446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33061446"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rui Mao, Zheng Wang, Yuanchuan Zhang, et al. 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