{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐coding RNA 01108 (LINC01108) has been implicated in the pathogenesis of major depressive disorder (MDD) through genetic association studies. In particular, a single nucleotide polymorphism (rs12526133) located within LINC01108 was found to be strongly associated with MDD, and expression analyses in peripheral blood cells of affected patients versus controls suggest that LINC01108 may influence disease susceptibility. Although the precise molecular function of LINC01108 remains to be fully elucidated, this evidence indicates that genetic variation within this intergenic lncRNA can alter its expression or regulatory capacity, thereby potentially contributing to the underlying mechanisms of MDD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ning Ye, Shuquan Rao, Tingfu Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intergenic variants may predispose to major depression disorder through regulation of long non-coding RNA expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2016.11.041"}], "href": "https://doi.org/10.1016/j.gene.2016.11.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27940106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27940106"}]}]}]}