{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01111 is a long noncoding RNA that functions as a tumor suppressor in pancreatic cancer. In one study, LINC01111 was found to be markedly downregulated in pancreatic cancer tissues and patient plasma, with low expression correlating with advanced TNM stages and poorer survival outcomes. Functional experiments demonstrated that overexpression of LINC01111 significantly inhibited cell proliferation, cell cycle progression, invasion, migration, tumorigenesis, and metastasis, whereas its knockdown enhanced these malignant behaviors. Mechanistically, LINC01111 mediates its suppressive effects by sequestering miR-3924, which leads to the upregulation of DUSP1 and subsequent inactivation of the SAPK/JNK signaling pathway. Additional reviews of long noncoding RNAs in pancreatic cancer further support the tumor‐suppressive role of LINC01111, underscoring its potential as a diagnostic and prognostic biomarker as well as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shutao Pan, Ming Shen, Min Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01111 suppresses pancreatic cancer aggressiveness by regulating DUSP1 expression via microRNA-3924."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-2123-y"}], "href": "https://doi.org/10.1038/s41419-019-2123-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31767833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31767833"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Soudeh Ghafouri-Fard, Mohadeseh Fathi, Tianyue Zhai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNAs: Novel Biomarkers for Pancreatic Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom11111665"}], "href": "https://doi.org/10.3390/biom11111665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34827663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34827663"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "K T Ramya Devi, Dharshene Karthik, TharunSelvam Mahendran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNAs: role and contribution in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transcription (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21541264.2021.1922071"}], "href": "https://doi.org/10.1080/21541264.2021.1922071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34036896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34036896"}]}]}]}