{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01115 is a long non‐coding RNA that remains largely uncharacterized but has emerged from epigenetic studies as a potential player in the pathogenesis of schizophrenia. In a genome‐wide survey of chromatin modifications in prefrontal cortical neurons from schizophrenic patients, LINC01115 was identified among several non‐coding RNA genes showing disease‐specific alterations in histone H3-K4 trimethylation marks, suggesting that its dysregulated expression or chromatin state may contribute to pathogenic gene regulatory networks in the brain."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the exact function of LINC01115 in neuronal biology has yet to be elucidated, its implication in a brain region critical for cognitive function and its association with epigenetic disturbances support a role in modulating neuronal gene expression, possibly impacting pathways such as oxidative stress and cell motility that have been linked to schizophrenia. In contrast, other studies investigating genetic interactions in obesity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and epigenetic influences on body composition"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "did not report on LINC01115, underscoring that its relevance may be more specific to neuropsychiatric rather than metabolic disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fedor E Gusev, Denis A Reshetov, Amanda C Mitchell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-019-0596-1"}], "href": "https://doi.org/10.1038/s41398-019-0596-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31624234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31624234"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rishika De, Ting Hu, Jason H Moore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BioData Min (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13040-015-0077-x"}], "href": "https://doi.org/10.1186/s13040-015-0077-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26715945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26715945"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Peter Rzehak, Marcela Covic, Richard Saffery, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA-Methylation and Body Composition in Preschool Children: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-13099-4"}], "href": "https://doi.org/10.1038/s41598-017-13099-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29084944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29084944"}]}]}]}