{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01118 is a long non‐coding RNA that has been implicated in distinct, context‐dependent regulatory roles. In epithelial ovarian cancer, for example, LINC01118 is markedly upregulated in both tumor tissues and paclitaxel‐resistant cells, where it acts as an oncogene by promoting cell migration and invasion while inhibiting apoptosis. Mechanistic studies have demonstrated that LINC01118 contributes to chemoresistance by targeting microRNA‐134, leading to altered expression of the drug transporter ABCC1 ("}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "). In reproductive biology, LINC01118 has been identified as one of the abundant lncRNAs in human metaphase II oocytes, suggesting a role in chromatin remodeling, maintenance of cell pluripotency, and early embryonic development based on co‐expression network predictions in the cumulus–oocyte complex ("}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "). Furthermore, transcriptomic analyses during ovarian follicle development indicate that dynamic changes in lncRNA expression—including that of LINC01118—may contribute to the regulation of early follicle maturation ("}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "). Although genome‐wide expression studies in diabetic skin ("}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ") and paclitaxel‐resistant non‐small cell lung cancer ("}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ") provide important insights into disease mechanisms, they do not specifically address the function of LINC01118.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cong Shi, Min Wang "}, {"type": "b", "children": [{"type": "t", "text": "LINC01118 Modulates Paclitaxel Resistance of Epithelial Ovarian Cancer by Regulating miR-134/ABCC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.910932"}], "href": "https://doi.org/10.12659/MSM.910932"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30521500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30521500"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Julien Bouckenheimer, Patricia Fauque, Charles-Henri Lecellier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential long non-coding RNA expression profiles in human oocytes and cumulus cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-20727-0"}], "href": "https://doi.org/10.1038/s41598-018-20727-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29396444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29396444"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Emil H Ernst, Julie Nielsen, Malene B Ipsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome Analysis of Long Non-coding RNAs and Genes Encoding Paraspeckle Proteins During Human Ovarian Follicle Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2018.00078"}], "href": "https://doi.org/10.3389/fcell.2018.00078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30087896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30087896"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Eri Takematsu, Adrianne Spencer, Jeff Auster, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0225267"}], "href": "https://doi.org/10.1371/journal.pone.0225267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32084158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32084158"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Farong Zang, Yuanquan Rao, Xinhai Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Shikonin suppresses NEAT1 and Akt signaling in treating paclitaxel-resistant non-small cell of lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s10020-020-00152-8"}], "href": "https://doi.org/10.1186/s10020-020-00152-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32268876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32268876"}]}]}]}