{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01119, a long non‐coding RNA, has emerged as a multifaceted regulator in diverse biological contexts including tumor biology, stem cell differentiation, and neuropathic pain. In colorectal cancer cells, LINC01119 was identified as a novel hypoxia‐responsive lncRNA among several others that are differentially expressed during hypoxic stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " During the adipogenic differentiation of adipose‐derived stem cells, LINC01119 was found to be among the lncRNAs potentially involved in regulating adipogenesis, possibly through acting as a competing endogenous RNA or via co‐expression networks with key target genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the context of mesenchymal stem cells, LINC01119 functions as a negative regulator of osteogenic differentiation by modulating the Wnt signaling pathway through targeting FZD4, with its expression being directly influenced by the transcription factor EBF3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, evidence from neuropathic pain models indicates that LINC01119 is upregulated in association with pain hypersensitivity, where it promotes the stabilization and increased expression of brain‐derived neurotrophic factor (BDNF) mRNA by forming a complex with the RNA binding protein ELAVL1; this mechanism contributes to neuroinflammation and pain progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In addition, mesenchymal stem/stromal cell interactions in triple‐negative breast cancer stimulate robust LINC01119 expression in cancer cells, which in turn induces SOCS5 expression, thereby enhancing tumor growth and progression; the LINC01119–SOCS5 axis correlates with poor prognosis in these patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Finally, LINC01119 has also been included in a signature panel of lncRNAs associated with recurrence prognoses in cervical cancer, suggesting its potential as a prognostic biomarker in oncological settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi Han, Xiaoyan Wang, Enqiang Mao, et al. 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