{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic noncoding RNA 01121 (LINC01121) has been implicated in the regulation of cellular processes involved in pathological tissue remodeling. In studies examining intervertebral disc degeneration (IDD), LINC01121 was found to be up‐regulated in nucleus pulposus cells upon exposure to inflammatory stimuli (e.g., IL‑1β and TNF‑α) and in IDD specimens, with its expression positively correlating with the degeneration grade (1). Functionally, ectopic expression of LINC01121 enhanced cell proliferation, promoted the expression of markers for extracellular matrix degradation—such as matrix metalloproteases (MMP‑3) and aggrecanases (ADAMTS5)—and increased secretion of pro‑inflammatory cytokines, while concurrently suppressing collagen II synthesis. Mechanistically, LINC01121 reduces miR‑150‑5p levels, thereby de‐repressing its target, MMP‑16, which in turn contributes to matrix degradation in the disc environment (1)."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In another context, treatment with metformin in breast cancer cells resulted in the up‑regulation of several long noncoding RNAs including LINC01121, suggesting that this lncRNA may also be involved in epigenetic regulatory networks influencing cell cycle and apoptotic pathways (2). Although the functional consequences of LINC01121 up‑regulation in this setting require further elucidation, preliminary evidence indicates that it might participate in cellular responses to therapeutic intervention, potentially affecting tumor growth and progression.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, initial knockdown studies (3) hint at a broader role for LINC01121 in modulating disease‐related cellular pathways. Collectively, these findings support a role for LINC01121 in promoting pathological cell proliferation, extracellular matrix remodeling, and inflammation in IDD, while also suggesting that it may be involved in epigenetic responses in cancer. Further studies are warranted to fully characterize the mechanistic basis of LINC01121 action and its potential as a therapeutic target.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "b", "children": [{"type": "t", "text": "References:"}]}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "<br>\n (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "<br>\n (3)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xin Chen, Zheng Li, Derong Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01121 induced intervertebral disc degeneration via modulating miR-150-5p/MMP16 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3231"}], "href": "https://doi.org/10.1002/jgm.3231"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32436632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32436632"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yongye Huang, Ziyan Zhou, Jin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA MALAT1 participates in metformin inhibiting the proliferation of breast cancer cell."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16742"}], "href": "https://doi.org/10.1111/jcmm.16742"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34164906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34164906"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhuolu Wang, Pinghu Wang, Lin Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Intergenic Non-Coding RNA 01121 Promotes Breast Cancer Cell Proliferation, Migration, and Invasion via the "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-150-5p"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "/HMGA2 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S230367"}], "href": "https://doi.org/10.2147/CMAR.S230367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31920395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31920395"}]}]}]}