{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have underscored the diverse roles of long non‐coding RNAs in both development and cancer. For instance, transcriptome and chromatin‐accessibility analyses during early cardiomyocyte differentiation hinted at novel noncoding RNAs as integral components of transcriptional regulatory networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of cancer, other lncRNAs such as LINC00096 have been shown to promote tumor progression in triple‐negative breast cancer by acting as a molecular sponge for miR-383-5p to ultimately elevate RBM3 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In contrast, investigations into LINC01124 in non-small cell lung cancer revealed that its expression is significantly downregulated in tumor tissues compared to normal lung tissues, with lower levels particularly evident in older patients and those with distant metastasis. Functional assays demonstrated that ectopic upregulation of LINC01124 significantly inhibited NSCLC cell proliferation, migration, and invasion, suggesting a tumor suppressor role for LINC01124 in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qing Liu, Chao Jiang, Jin Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Temporal Profiling of Transcriptome and Open Chromatin of Early Cardiomyocyte Differentiation Derived From hiPSCs and hESCs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.116.310456"}], "href": "https://doi.org/10.1161/CIRCRESAHA.116.310456"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28663367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28663367"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yanyan Tian, Shuguan Xia, Mingde Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00096 Promotes the Proliferation and Invasion by Sponging miR-383-5p and Regulating RBM3 Expression in Triple-Negative Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S229659"}], "href": "https://doi.org/10.2147/OTT.S229659"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31819536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31819536"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zi-Bo Wang, Hong-Yan Zhang, Ji-Bin Lu "}, {"type": "b", "children": [{"type": "t", "text": "Expression and Effects of Long Non-Coding RNA, LINC01124, in Non-Small Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S214049"}], "href": "https://doi.org/10.2147/OTT.S214049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32099381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32099381"}]}]}]}