{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01126 has been implicated in distinct pathological contexts. In periodontitis, LINC01126 is markedly upregulated in periodontal tissues exposed to a hypoxic microenvironment. Functional studies in human periodontal ligament cells revealed that LINC01126 acts by “sponging” miR‑518a‑5p, which in turn leads to increased expression of hypoxia-inducible factor‐1α. This regulation activates downstream MAPK signaling, resulting in suppressed cell proliferation, enhanced apoptosis, and increased expression of inflammatory cytokines—thereby contributing to periodontitis pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate context, LINC01126 was identified as one of the 15 long noncoding RNAs in a prognostic signature that effectively predicts the outcome of advanced melanoma patients treated with anti‐PD‑1 monotherapy. This finding highlights its potential utility as a biomarker to improve patient stratification and personalize immunotherapy approaches."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mi Zhou, Hui Hu, Yineng Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA 01126 promotes periodontitis pathogenesis of human periodontal ligament cells via miR-518a-5p/HIF-1α/MAPK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12957"}], "href": "https://doi.org/10.1111/cpr.12957"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33231338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33231338"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jian-Guo Zhou, Bo Liang, Jian-Guo Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of 15 lncRNAs Signature for Predicting Survival Benefit of Advanced Melanoma Patients Treated with Anti-PD-1 Monotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10050977"}], "href": "https://doi.org/10.3390/cells10050977"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33922038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33922038"}]}]}]}