{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Dysregulation of long non‐coding RNAs is increasingly recognized as a critical factor in cancer, with several studies demonstrating their prognostic and functional relevance across different tumor types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In particular, the lncRNA LINC01127 has been identified as an oncogenic factor in ovarian cancer. Its expression is significantly elevated in ovarian tumor tissues compared with normal ovarian tissues, and high levels are negatively correlated with patient prognosis. Functional studies have shown that LINC01127 facilitates cell cycle progression—its knockdown results in cell cycle arrest at the G1/G0 phase, reduces cellular proliferation, and suppresses tumor growth in nude mouse models. Mechanistically, the oncogenic effects of LINC01127 are linked to its ability to promote the phosphorylation of key regulators in the AKT and ERK signaling pathways, thereby driving tumorigenesis. \n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mingwei Chen, Baoquan Liu, Jianbing Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel seven-long non-coding RNA signature predicts survival in early stage lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14781"}], "href": "https://doi.org/10.18632/oncotarget.14781"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28122330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28122330"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sandra Regina Maruyama, Carlos Alessandro Fuzo, Antonio Edson R Oliveira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insight Into the Long Noncoding RNA and mRNA Coexpression Profile in the Human Blood Transcriptome Upon "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Leishmania infantum"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2022.784463"}], "href": "https://doi.org/10.3389/fimmu.2022.784463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35370994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35370994"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shuo Wang, Enmao Wang, Qincong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uncovering Potential lncRNAs and mRNAs in the Progression From Acute Myocardial Infarction to Myocardial Fibrosis to Heart Failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cardiovasc Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcvm.2021.664044"}], "href": "https://doi.org/10.3389/fcvm.2021.664044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34336943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34336943"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Li Jing, Mi Gong, Xiaoyuan Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01127 promotes the development of ovarian tumors by regulating the cell cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30787997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30787997"}]}]}]}