{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01128 is emerging as a multifunctional long non‐coding RNA that plays diverse roles in human diseases by modulating gene expression through competing endogenous RNA (ceRNA) mechanisms. In cervical cancer, LINC01128 is significantly upregulated and promotes cell proliferation, migration, and invasion while inhibiting apoptosis by binding to miR‑383‑5p to release its target SFN, thereby enhancing oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in osteosarcoma, upregulated LINC01128 acts as a sponge for miR‑299‑3p to increase MMP2 expression and subsequently activate the Wnt/β‑catenin pathway, which facilitates tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In pancreatic cancer, LINC01128 exerts oncogenic functions by sequestering miR‑561‑5p, resulting in enhanced lactate dehydrogenase A (LDHA) expression that promotes proliferation, migration, invasion, and epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In contrast, in acute myeloid leukemia, LINC01128 appears to play a tumor‐suppressive role by competitively binding miR‑4260, which leads to upregulation of NR3C2 and repression of leukemic cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Beyond cancer, altered expression of LINC01128 has also been implicated in other conditions; for example, its downregulation in Parkinson disease suggests potential relevance in neurodegeneration"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while its inclusion in ceRNA networks associated with systemic sclerosis–related interstitial lung disease and its differential expression in multiple myeloma underscore its broader involvement in disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these studies indicate that LINC01128 modulates key molecular pathways through miRNA sponging and consequent regulation of downstream target genes, making it a promising biomarker and potential therapeutic target in various pathological contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi Hu, Yan Ma, Jie Liu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LINC01128 resisted acute myeloid leukemia through regulating miR-4260/NR3C2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2020.1740054"}], "href": "https://doi.org/10.1080/15384047.2020.1740054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32338183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32338183"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maryam Yousefi, Maryam Peymani, Kamran Ghaedi, et al. 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