{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In glioblastoma, LINC01132 is identified as one of the downstream target genes of hypoxia‐inducible factor 1 (HIF‑1). In this context, epigenetic mono‐ and di‑methylation of HIF‑1α at lysine 674 by the lysine methyltransferases G9a and GLP suppresses HIF‑1 transcriptional activity and reduces the expression of its target genes, including LINC01132. Thus, when hypoxia downregulates G9a, HIF‑1 activity—and consequently LINC01132 expression—is maintained, potentially contributing to enhanced cell migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In epithelial ovarian cancer (EOC), LINC01132 is overexpressed and is significantly linked to poor patient prognosis. Functional studies demonstrate that depletion of LINC01132 produces cancer‑suppressive effects by inhibiting proliferation, migration, and invasion while promoting apoptosis. Mechanistically, LINC01132 appears to function as a molecular sponge interacting with microRNA‑431‑5p, leading to the upregulation of the transcription factor SOX9, which in turn facilitates oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although broader genomic analyses of ovarian cancer have identified numerous dysregulated long non‑coding RNAs"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", subsequent investigations have implicated LINC01132 as an independent prognostic factor among autophagy‑related lncRNAs. This further supports its potential value as a biomarker and as a contributor to tumor progression in ovarian cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight that the function of LINC01132 is context dependent. In glioblastoma, its expression is indirectly modulated by hypoxia‑induced epigenetic mechanisms that affect HIF‑1 activity and cell mobility, whereas in ovarian cancer, its overexpression promotes oncogenic behaviors through interactions with microRNAs and transcription factors, and it serves as a prognostic marker.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Bao, Yan Chen, Hsien-Tsung Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gky449"}], "href": "https://doi.org/10.1093/nar/gky449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29860315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29860315"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Zhu, Xiangming Xiao, Jinqin Chen "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of the long noncoding RNA LINC01132 alleviates the oncogenicity of epithelial ovarian cancer by regulating the microRNA‑431‑5p/SOX9 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2021.4984"}], "href": "https://doi.org/10.3892/ijmm.2021.4984"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34132375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34132375"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jing Wang, Yongju Tian, Hui Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2171"}], "href": "https://doi.org/10.1002/cam4.2171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31016892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31016892"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chan Meng, Jie-Qiong Zhou, Yong-Sheng Liao "}, {"type": "b", "children": [{"type": "t", "text": "Autophagy-related long non-coding RNA signature for ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0300060520970761"}], "href": "https://doi.org/10.1177/0300060520970761"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33179541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33179541"}]}]}]}