{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01133 is a long intergenic non‐coding RNA with highly context‐dependent roles in human disease. In several cancer types its expression level is dysregulated and its function appears to depend on the tissue context. For instance, in gastric cancer studies LINC01133 has been reported either as downregulated—suppressing epithelial–mesenchymal transition (EMT) and metastasis by acting as a competing endogenous RNA (ceRNA) to sequester miR‑106a‑3p that in turn upregulates APC and inactivates the Wnt/β‑catenin pathway"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "—or as upregulated to promote cell cycle progression by sponging miR‑145‑5p and facilitating YES1‐dependent nuclear translocation of YAP1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In colorectal and breast cancers, reduced LINC01133 expression has been associated with enhanced invasion, metastasis and poorer overall survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " In contrast, in non‐small cell lung cancer LINC01133 is typically overexpressed, where it exerts oncogenic effects by interacting with epigenetic regulators EZH2 and LSD1 to repress tumor suppressor genes such as KLF2, P21 and E-cadherin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In pancreatic ductal adenocarcinoma and hepatocellular carcinoma, elevated levels of LINC01133 have been linked to increased proliferation, EMT and metastasis, acting through mechanisms that include modulation of chromatin status (via EZH2 binding) and ceRNA activity toward microRNAs such as miR‑199a‑5p and by repressing DKK1 to activate the Wnt pathway."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": " Similarly, in cervical cancer some reports demonstrate an oncogenic role through a ceRNA network with miR‑4784 leading to increased AHDC1 expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", whereas in esophageal squamous cell carcinoma LINC01133 is downregulated and may serve as a protective factor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond solid tumors, LINC01133 also plays roles in non-neoplastic contexts. In ovarian and endometrial cancers, both oncogenic and tumor-suppressive effects have been described. In epithelial ovarian cancer, for example, LINC01133 has been reported to promote metastasis via sponging miR‑495‑3p and upregulating TPD52"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", while in another ovarian study it functions as a miR‑205 sponge to upregulate LRRK2 and inhibit cancer cell aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " In endometrial carcinoma, LINC01133 knockdown reduces proliferation, migration and invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "; a review also emphasizes its dual, tissue-dependent functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its roles in cancer, LINC01133 has been implicated in the regulation of osteogenic differentiation. In dental pulp stem cells, elevated levels of LINC01133 suppress osteogenic differentiation through sponging miR‑199b‑5p to upregulate AKT3"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ", whereas in human periodontal ligament stem cells, LINC01133 promotes osteogenesis by modulating the miR‑30c/BGLAP axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Circulating forms of LINC01133, including those packaged in exosomes found in serum or derived from normal epithelial cells, have also been explored as non-invasive biomarkers for cancer diagnosis and prognosis in cervical and bladder cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Additional studies in renal cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": ", osteosarcoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": ", and melanoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": "further underscore the importance of LINC01133 in regulating tumor proliferation, invasion and metastasis via its interactions with distinct microRNAs (e.g., miR‑760, miR‑422a) and downstream effectors. Moreover, in cardiomyocytes, the cardioprotective effects of sevoflurane preconditioning have been linked to modulation of the miR‑30a‑5p/LINC01133 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies illustrate that LINC01133 functions through diverse molecular mechanisms—most notably by acting as a ceRNA and by recruiting chromatin modulators—to regulate key genes involved in cell cycle progression, EMT, and metastasis. Its paradoxical roles as either oncogene or tumor suppressor highlight its tissue-specific functions and suggest that LINC01133 holds promise as both a prognostic biomarker and a therapeutic target across multiple disease contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}, {"type": "fg_fs", "start_ref": "25", "end_ref": "27"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, emerging data in endometriosis also suggest that LINC01133 may play a role in modulating ectopic endometrial growth, although further studies are needed to clarify its functions in benign gynecological conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xian-Zi Yang, Tian-Tian Cheng, Qing-Jun He, et al. 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