{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01134 is a long intergenic non‐coding RNA that is frequently upregulated in hepatocellular carcinoma (HCC) and is associated with poor prognosis. Its elevated expression contributes to multiple aspects of HCC progression and therapy resistance. For instance, in oxaliplatin‐resistant HCC, LINC01134 upregulation—promoted by the demethylase LSD1—enhances chemoresistance by recruiting the transcription factor SP1 to the p62 promoter, thereby activating an anti‐oxidative pathway that sustains cell viability, mitigates apoptosis, and preserves mitochondrial homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, LINC01134 is transcriptionally activated by YY1 and engages in a positive feedback loop by acting as a sponge for miR-324-5p and interacting with IGF2BP1 to stabilize YY1 mRNA, which collectively promotes proliferation, migration, and epithelial-mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Its role is not limited to chemoresistance; LINC01134 also participates in the DNA damage response, thereby contributing to radioresistance in HCC cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, through functioning as a competitive endogenous RNA—for example, by sponging miR-4784 to upregulate SSRP1—LINC01134 further drives tumorigenesis, invasiveness, and recurrence, correlating with advanced disease stage and reduced overall survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Luyuan Ma, An Xu, Lei Kang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic noncoding RNA01134 accelerates hepatocellular carcinoma progression by sponging microRNA-4784 and downregulating structure specific recognition protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2020.1818508"}], "href": "https://doi.org/10.1080/21655979.2020.1818508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32970959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32970959"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chao Wang, Yan Chen, Kunlun Chen, et al. 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