{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01135 is a long non‐coding RNA that has recently been identified as part of an m5C‐related regulatory network in prostate cancer. In one study, a prognostic signature based on m5C‐associated lncRNAs was developed using rigorous statistical methods (including univariate Cox and LASSO regression), and LINC01135 was among the 17 lncRNAs incorporated into this model (1). Although the detailed molecular functions of LINC01135 remain to be fully elucidated, its inclusion in this signature suggests that it may contribute to the regulation of gene expression through m5C methylation processes, thereby potentially influencing tumor progression and patient outcomes in prostate cancer.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Further research is needed to define the specific mechanistic roles of LINC01135 in RNA modification and its impact on the tumor microenvironment. This could eventually aid in refining prognostic models and therapeutic strategies targeting the m5C modification machinery.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Citation:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ke Wang, Weibo Zhong, Zining Long, et al. "}, {"type": "b", "children": [{"type": "t", "text": "5-Methylcytosine RNA Methyltransferases-Related Long Non-coding RNA to Develop and Validate Biochemical Recurrence Signature in Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Mol Biosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fmolb.2021.775304"}], "href": "https://doi.org/10.3389/fmolb.2021.775304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34926580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34926580"}]}]}]}