{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Telomere biology plays a broad role in regulating gene expression beyond telomere‐specific functions, as highlighted by studies showing telomere length–dependent modulation of distal promoters by shelterin components."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of hepatocellular carcinoma (HCC), the long intergenic non‐coding RNA (lncRNA) LINC01136 has emerged as a component of prognostic lncRNA signatures. In one study, LINC01136 was integrated with other lncRNAs into an 11‐lncRNA signature that, through a competitive endogenous RNA network involving miRNAs (e.g., miR-195, miR-199b, miR-326, miR-424, and let-7c) and the upregulated oncogene E2F2, was associated with poor patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In another investigation focusing on hepatitis B virus–related HCC, LINC01136 was one of eight lncRNAs used to construct a risk score model that robustly differentiated overall survival, with evidence indicating that it coexpresses with the gene SFN as part of cell cycle–related regulatory networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that LINC01136 may function as a key regulatory node in HCC by participating in ceRNA-mediated interactions and gene coexpression mechanisms that influence cell cycle and oncogenic pathways. Moreover, its consistent association with patient outcomes underscores its potential utility as both a prognostic biomarker and a therapeutic target in HCC.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ananda Kishore Mukherjee, Shalu Sharma, Suman Sengupta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1007782"}], "href": "https://doi.org/10.1371/journal.pgen.1007782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30439955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30439955"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Anmei Wang, Junhua Lei "}, {"type": "b", "children": [{"type": "t", "text": "Identification of an 11-lncRNA signature with high performance for predicting the prognosis of hepatocellular carcinoma using bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000023749"}], "href": "https://doi.org/10.1097/MD.0000000000023749"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33592832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33592832"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaonan Zhao, Zhenzi Bai, Chenghua Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a Novel Eight-lncRNA Prognostic Signature for HBV-HCC and Analysis of Their Functions Based on Coexpression and ceRNA Networks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8765461"}], "href": "https://doi.org/10.1155/2020/8765461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32382578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32382578"}]}]}]}