{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01137 has emerged as a multifunctional long noncoding RNA implicated in several human diseases, most notably in various cancers and immune‐related disorders. In oral squamous cell carcinoma, LINC01137 is significantly upregulated in primary tumors where it promotes cell proliferation, migration, and invasion; its oncogenic activity is mediated in part by direct binding to miR‑22‑3p, which negatively regulates its expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In high‐grade serous ovarian cancer, genetic analyses have identified LINC01137 among several genes at the 1p34.3 risk locus whose increased expression is associated with the risk allele, suggesting its potential contribution to ovarian tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, LINC01137 frequently appears in multiple prognostic signatures for lung adenocarcinoma; it is incorporated into autophagy‐related, oncosis‐related, redox‐related, and ferroptosis/iron metabolism–related lncRNA models, indicating a multifaceted role in modulating tumor metabolism, cell death pathways, and overall disease progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": " In addition, immune-related studies have linked LINC01137 to distinct immunomodulatory networks. For instance, in psoriasis, its expression correlates with specific patterns of immune cell infiltration and drug response, while in the context of ossification of the ligamentum flavum, it has been predicted to participate in immunoregulatory interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these studies highlight that LINC01137 functions as an oncogenic regulator involved in promoting malignant cellular behaviors and modulating diverse biological processes—including proliferation, metabolic reprogramming, cell death, autophagy, and immune responses—thereby representing a promising biomarker and potential therapeutic target across multiple disease contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yong Du, Haiyan Yang, Yue Li, et al. 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