{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01138 is emerging as an oncogenic long non‐coding RNA that is frequently amplified and overexpressed in several cancer types. In clear cell renal cell carcinoma, for example, LINC01138 is highly expressed and promotes tumor growth by interacting with PRMT5 to enhance the arginine methylation and stability of SREBP1, thereby stimulating lipid desaturation and cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, amplification of LINC01138 and its stabilization by IGF2BP1/3 similarly drive malignant behavior through its physical association with PRMT5, leading to increased tumor cell proliferation, invasion, and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In gastric cancer, LINC01138 functions as a competing endogenous RNA by sponging miR-1273e, which in turn results in activation of the MAPK signaling cascade; this axis enhances cell proliferation, invasion, and migration while attenuating apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in prostate cancer, LINC01138 is identified as one of several androgen receptor–targeted lncRNAs that promote cellular proliferation and confer resistance to apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these findings highlight the multifaceted role of LINC01138 in modulating key oncogenic pathways across different tumor types, underscoring its potential as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xi Zhang, Jian Wu, Congcong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The LINC01138 interacts with PRMT5 to promote SREBP1-mediated lipid desaturation and cell growth in clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.11.036"}], "href": "https://doi.org/10.1016/j.bbrc.2018.11.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30446222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30446222"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhe Li, Jiwei Zhang, Xinyang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-04006-0"}], "href": "https://doi.org/10.1038/s41467-018-04006-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29679004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29679004"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guang-Xian Dou, Jin-Na Zhang, Ping Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Intergenic Non-Protein-Coding RNA 01138 Accelerates Tumor Growth and Invasion in Gastric Cancer by Regulating miR-1273e."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.914248"}], "href": "https://doi.org/10.12659/MSM.914248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30902962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30902962"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xuechao Wan, Wenhua Huang, Shu Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of androgen-responsive lncRNAs as diagnostic and prognostic markers for prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11391"}], "href": "https://doi.org/10.18632/oncotarget.11391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27556357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27556357"}]}]}]}