{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01139 has been implicated as an oncogenic long non‐coding RNA in multiple tumor types. In hepatocellular carcinoma (HCC), LINC01139 is markedly overexpressed and its elevated levels correlate with advanced TNM stage, lymph node metastasis, and poor patient prognosis. Functional studies demonstrate that silencing LINC01139 suppresses cell proliferation, colony formation, and metastasis. Mechanistically, LINC01139 acts as a molecular sponge for miR‑30, leading to the upregulation of the transcription factor MYBL2, thereby promoting oncogenic pathways in HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In ovarian carcinoma, LINC01139 emerges as one of a panel of lncRNAs that are significantly associated with pathological grade and recurrence risk. Bioinformatics and clinical analyses have identified LINC01139 as an independent prognostic factor, with its dysregulated expression contributing to the mechanisms underlying ovarian cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zai-Bo Li, Hong-Tao Chu, Min Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01139 promotes the progression of hepatocellular carcinoma by upregulating MYBL2 via competitively binding to miR-30 family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.02.116"}], "href": "https://doi.org/10.1016/j.bbrc.2020.02.116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32115147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32115147"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ying Chen, Fangfang Bi, Yuanyuan An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of pathological grade and prognosis-associated lncRNA for ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28704"}], "href": "https://doi.org/10.1002/jcb.28704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31034644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31034644"}]}]}]}