{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study focused on prostate cancer, a comprehensive analysis of The Cancer Genome Atlas data led to the construction of a competing endogenous RNA network, through which several long noncoding RNAs were identified as candidate signatures associated with tumor stage progression and lymphatic metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Among these, LINC01141 emerged as one of the lncRNA signatures demonstrating potential diagnostic and prognostic value. Although the study broadly characterized multiple lncRNAs within the network, the inclusion of LINC01141 suggests that it may contribute to the regulatory mechanisms underpinning proliferation, cell cycle progression, apoptosis, migration, invasion, and adhesion in prostate cancer. Its coexpression with specific mRNAs implicated in metastasis supports the notion that LINC01141 could be targeted to modulate these oncogenic processes. Furthermore, by exploring the molecular interactions within this network, the antifungal compound econazole was identified as a promising therapeutic agent capable of restraining tumor growth and metastatic potential, thus underscoring the clinical relevance of the pathways in which LINC01141 may be involved."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaocong Pang, Ying Zhao, Jinhua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Competing Endogenous RNA and Coexpression Network Analysis for Identification of Potential Biomarkers and Therapeutics in association with Metastasis Risk and Progression of Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/8265958"}], "href": "https://doi.org/10.1155/2019/8265958"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31467637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31467637"}]}]}]}