{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A recent genome‐wide association study (GWAS) of atrial fibrillation (AF) identified an intergenic variant (rs72700114) located between the long noncoding RNA gene LINC01142 and METTL11B, which is associated with increased AF risk (1). Although the study did not directly characterize the molecular function of LINC01142, its genomic proximity to the AF‐associated variant implicates it as a potential regulatory element that may influence myocardial structure and electrical function. In concert with other findings linking sarcomere and cytoskeletal gene variants to AF, the association of this noncoding region suggests that LINC01142 might play a role in modulating cardiac electrophysiology and contributing to the pathogenesis of AF via effects on gene regulation and myocardial tissue integrity (1).\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rosa B Thorolfsdottir, Gardar Sveinbjornsson, Patrick Sulem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Missense Variant in PLEC Increases Risk of Atrial Fibrillation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Coll Cardiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jacc.2017.09.005"}], "href": "https://doi.org/10.1016/j.jacc.2017.09.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29050564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29050564"}]}]}]}