{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A recent study investigating the molecular mechanisms underlying subarachnoid hemorrhage (SAH) identified LINC01144 as one of the differentially expressed long non‐coding RNAs associated with the condition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Through comprehensive profiling that included screening of mRNAs, microRNAs, and lncRNAs followed by construction of competing endogenous RNA (ceRNA), protein–protein interaction, and drug–gene networks, the study revealed that LINC01144 is potentially involved in modulating inflammatory responses—most notably via the TNF signaling pathway. These findings suggest that LINC01144 not only contributes to the regulation of key inflammatory mediators but may also serve as a candidate biomarker for predicting the risk of SAH and guiding targeted therapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yifei Weng "}, {"type": "b", "children": [{"type": "t", "text": "Investigation of molecular regulation mechanism under the pathophysiology of subarachnoid hemorrhage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Open Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/biol-2021-0138"}], "href": "https://doi.org/10.1515/biol-2021-0138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35087950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35087950"}]}]}]}