{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01146 is a long non‐coding RNA with emerging roles in heterogeneous disease contexts. In hepatocellular carcinoma (HCC), LINC01146 has been found to be significantly downregulated in tumor tissues compared with adjacent normal tissues. Functional studies in HCC cells revealed that increased expression of LINC01146 suppresses cell proliferation, migration, and invasion while promoting apoptosis, ultimately inhibiting tumor growth both in vitro and in vivo. These findings suggest that LINC01146 may act as a tumor suppressor and serve as a valuable prognostic biomarker in HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate study focused on chronic rhinosinusitis with nasal polyps (CRSwNP) with comorbid asthma, transcriptome analysis identified LINC01146 as a hub long non‐coding RNA with dysregulated expression in nasal tissues from patients. Although the study was primarily designed to explore molecular signatures associated with type 2 inflammation, the identification of LINC01146 within the coexpression network indicates that it may play an important regulatory role in the inflammatory endotype observed in CRSwNP both with and without asthma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, another comprehensive analysis of long non‐coding RNAs in HCC underscored the diagnostic and prognostic potential of several lncRNAs. While this study did not specifically focus on LINC01146—highlighting other lncRNAs such as CRNDE, LINC01419, and LINC01093—it further establishes the critical importance of lncRNAs in the pathogenesis and clinical management of HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, the data indicate that LINC01146 functions as a cancer suppressor in HCC and may also be involved in modulating inflammatory responses in CRSwNP with comorbid asthma. These findings emphasize the multifaceted roles of long non‐coding RNAs in disease, suggesting that LINC01146 holds promise both as a prognostic marker in cancer and as a key component in the molecular framework of inflammatory disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoyun Ma, Meile Mo, Chao Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Liver-specific LINC01146, a promising prognostic indicator, inhibits the malignant phenotype of hepatocellular carcinoma cells both in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-021-03225-2"}], "href": "https://doi.org/10.1186/s12967-021-03225-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35101062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35101062"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ming Wang, Xiangting Bu, Ge Luan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct type 2-high inflammation associated molecular signatures of chronic rhinosinusitis with nasal polyps with comorbid asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Allergy (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13601-020-00332-z"}], "href": "https://doi.org/10.1186/s13601-020-00332-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32637070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32637070"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Meiyu Dai, Siyuan Chen, Xiaomou Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnosis, prognosis and bioinformatics analysis of lncRNAs in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.21329"}], "href": "https://doi.org/10.18632/oncotarget.21329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29221168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29221168"}]}]}]}