{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01149, a long noncoding RNA, has been characterized in one study as a regulatory hub that modulates host immune responses in chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In this work, a common variant (rs2844512 G > C) within LINC01149 was found to enhance spontaneous HBV recovery while at the same time increasing HCC risk. Functional assays revealed that this variant creates a novel binding site for miR‑128‑3p. By acting as a miRNA sponge, LINC01149 increases the expression of MICA, a stress-induced ligand capable of recruiting natural killer (NK) cells. Although this recruitment can facilitate the lysis of HBV-infected cells, the concomitant release of soluble MICA may promote NK cell exhaustion and thereby favor tumor immune evasion.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n While other studies have explored the genetic and environmental determinants in related chronic diseases such as asthma and chronic obstructive pulmonary disease (COPD)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and an additional abstract provides further context on noncoding regulatory elements"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", the specific molecular function of LINC01149 is most clearly elucidated in the HBV-HCC setting.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rong Zhong, Jianbo Tian, Mingpeng Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01149 variant modulates MICA expression that facilitates hepatitis B virus spontaneous recovery but increases hepatocellular carcinoma risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-019-1117-7"}], "href": "https://doi.org/10.1038/s41388-019-1117-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31754211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31754211"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gyu Young Hur, David H Broide "}, {"type": "b", "children": [{"type": "t", "text": "Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Allergy Asthma Immunol Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4168/aair.2019.11.5.604"}], "href": "https://doi.org/10.4168/aair.2019.11.5.604"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31332973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31332973"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lystra P Hayden, Michael H Cho, Benjamin A Raby, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Respir Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12931-018-0890-0"}], "href": "https://doi.org/10.1186/s12931-018-0890-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30373671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30373671"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jerzy K Kulski "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "HCP5"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", a Hybrid HLA Class I Endogenous Retroviral Gene: Structure, Expression, and Disease Associations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells8050480"}], "href": "https://doi.org/10.3390/cells8050480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31137555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31137555"}]}]}]}