{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01150 is a long non‐coding RNA that has recently been identified as a component of a genomic instability–associated signature in cancer. In a study of gastric cancers, LINC01150 (together with other lncRNAs such as LINC02678, HOXA10‐AS, RHOXF1‐AS1, AC010789.1, and TGFB2‐AS1) was shown to correlate with the accumulation of somatic mutations and was independently prognostic for patient survival. Expression of LINC01150 within this signature was further associated with variations in chemotherapy sensitivity and the tumor immune microenvironment, suggesting that it may serve as a biomarker reflecting underlying genomic instability and as a potential indicator to help tailor therapeutic interventions (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jie Sun, Quan Jiang, Hao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic instability-associated lncRNA signature predicts prognosis and distinct immune landscape in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/atm-21-3569"}], "href": "https://doi.org/10.21037/atm-21-3569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34532463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34532463"}]}]}]}