{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01152, a long intergenic noncoding RNA, has emerged as an oncogenic regulator in distinct tumor contexts. In glioblastoma multiforme (GBM), LINC01152 is significantly upregulated and promotes tumorigenesis by upregulating mastermind like transcriptional coactivator 2 (MAML2). Specifically, LINC01152 acts by sponging miR‐466 and recruiting SRSF1, which in turn facilitates MAML2 expression. The elevated MAML2 then engages in a positive regulatory feedback through the RBPJ/MAML2 transcription complex that activates the Notch signaling pathway, thereby enhancing cell proliferation and survival in GBM cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC), LINC01152 is similarly overexpressed following induction by the viral HBx protein. The increased levels of LINC01152 promote tumor growth by binding to the promoter region of interleukin‐23 (IL-23), which boosts its transcriptional activity. The resultant upregulation of IL-23 leads to elevated STAT3 and phosphorylated STAT3 levels, thereby contributing to enhanced cell proliferation and tumor development in HBV-associated HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings demonstrate that LINC01152 plays a crucial oncogenic role by modulating key regulatory pathways—Notch signaling in GBM and the IL-23/STAT3 signaling axis in HBV-related HCC—highlighting its potential as a therapeutic marker in these malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianheng Wu, Nannan Wang, Ying Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01152 upregulates MAML2 expression to modulate the progression of glioblastoma multiforme via Notch signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-03163-9"}], "href": "https://doi.org/10.1038/s41419-020-03163-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33483471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33483471"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tianshi Chen, Jinxian Pei, Jinjiang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HBx-related long non-coding RNA 01152 promotes cell proliferation and survival by IL-23 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.108877"}], "href": "https://doi.org/10.1016/j.biopha.2019.108877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31054511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31054511"}]}]}]}