{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In glioma, LINC01158 is highly expressed and functions as an oncogenic long non‐coding RNA. Mechanistically, LINC01158 acts as a competing endogenous RNA (ceRNA) by sponging miR‑6734‑3p, which leads to the upregulation of CENPK. The elevated CENPK levels, in turn, promote glioma cell proliferation and inhibit apoptosis, as demonstrated by multiple functional assays (e.g., qRT-PCR, EdU, colony formation, CCK‑8, caspase‑3 activity, and TUNEL assays). Subcellular fractionation and FISH analyses confirm that LINC01158 is predominantly localized in the cytoplasm—consistent with its role in sequestering miR‑6734‑3p. Together, these data suggest that LINC01158 is a key player in glioma development and may serve as a novel therapeutic target for modulating glioma progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhenxing Sun, Naili Wei, Shenglian Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01158 works as an oncogene in glioma via sponging miR-6734-3p to boost CENPK expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-021-01931-x"}], "href": "https://doi.org/10.1186/s12935-021-01931-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34044826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34044826"}]}]}]}