{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01164 appears to play a multifaceted role in human disease through its epigenetic regulation. In studies of nasal epithelial DNA methylation in children and adolescents exposed to violence and chronic stress, differential methylation of LINC01164 was identified as one of several CpG markers associated with environmental exposures such as maternal perceived stress and gun violence, potentially linking these exposures to the development of atopic asthma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, while analyses of stress‐related epigenomic changes in similar populations support the overall concept that environmental stressors may predispose to asthma via epigenetic mechanisms"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", separate investigations in hepatocellular carcinoma have highlighted LINC01164 as one of four methylation-regulated long non-coding RNAs whose expression levels serve as robust prognostic biomarkers. In these cancer studies, LINC01164 contributed to a risk scoring system that outperformed traditional staging methods and aided in predicting overall survival, underscoring its potential utility in individualized treatment strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qi Yan, Erick Forno, Andres Cardenas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exposure to violence, chronic stress, nasal DNA methylation, and atopic asthma in children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Pulmonol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ppul.25372"}], "href": "https://doi.org/10.1002/ppul.25372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33751861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33751861"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qi Yan, Erick Forno, Andres Cardenas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exposure to violence, chronic stress, nasal DNA methylation, and atopic asthma in children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "medRxiv (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/2020.11.03.20225250"}], "href": "https://doi.org/10.1101/2020.11.03.20225250"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33173928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33173928"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Le-En Liao, Dan-Dan Hu, Yun Zheng "}, {"type": "b", "children": [{"type": "t", "text": "A Four-Methylated lncRNAs-Based Prognostic Signature for Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes11080908"}], "href": "https://doi.org/10.3390/genes11080908"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32784402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32784402"}]}]}]}