{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01170 is a long noncoding RNA that is aberrantly overexpressed in endometrial carcinoma, with significantly higher expression levels detected in carcinoma tissues compared to adjacent normal tissues, and even more so in advanced stages of the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional studies demonstrated that silencing LINC01170 in endometrial carcinoma cell lines led to a marked decrease in cell proliferation, an arrest of the cell cycle at the G0/G1 phase, and a significant induction of apoptosis. Mechanistically, the knockdown of LINC01170 resulted in reduced activity of the AKT pathway, as evidenced by decreased phosphorylation of the AKT protein and subsequent downregulation of downstream effectors such as CDK2, CDK4, and Bcl-2. These findings suggest that LINC01170 promotes the progression of endometrial carcinoma by facilitating proliferation and cell cycle progression while inhibiting apoptosis via activation of the AKT signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhengzheng Zhang, Xiao Liu, Hao Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01170 promotes the progression of endometrial carcinoma by activating the AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J BUON (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30610803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30610803"}]}]}]}