{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A review of the four studies reveals that although long noncoding RNAs (lncRNAs) have been implicated in diverse biological processes—including gene–environment interactions in developmental defects (such as nonsyndromic cleft palate)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", immunomodulatory responses to fungal infections"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and molecular signal refinement for pulmonary arterial hypertension classification"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "as well as unique transcriptional signatures in PBMCs"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", none of the abstracts specifically address or provide functional data regarding LINC01181. In other words, while these studies support an overall critical role for lncRNAs in modulating gene expression and influencing disease processes, the precise function and mechanism of action for LINC01181 remain uncharacterized within these reports. Consequently, elucidating the role of LINC01181 in these various contexts awaits further dedicated investigation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Terri H Beaty, Ingo Ruczinski, Jeffrey C Murray, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Epidemiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gepi.20595"}], "href": "https://doi.org/10.1002/gepi.20595"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21618603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21618603"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Konstantin Riege, Martin Hölzer, Tilman E Klassert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Massive Effect on LncRNAs in Human Monocytes During Fungal and Bacterial Infections and in Response to Vitamins A and D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep40598"}], "href": "https://doi.org/10.1038/srep40598"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28094339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28094339"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Song Cui, Qiang Wu, James West, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Machine learning-based microarray analyses indicate low-expression genes might collectively influence PAH disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Comput Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pcbi.1007264"}], "href": "https://doi.org/10.1371/journal.pcbi.1007264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31404060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31404060"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "You-Hua Yuan, Jian Liu, Yuan-Gang You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptomic Analysis of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Mycobacterium leprae-"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "Stimulated Response in Peripheral Blood Mononuclear Cells Reveal Potential Biomarkers for Early Diagnosis of Leprosy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Infect Microbiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcimb.2021.714396"}], "href": "https://doi.org/10.3389/fcimb.2021.714396"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34993156"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34993156"}]}]}]}