{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01183 has emerged as a lncRNA of interest in oncology, with its potential utility highlighted in studies across different cancer types. In a genome‐scale analysis of gastric cancer cells treated with a novel anticancer bioactive peptide and oxaliplatin, a broad panel of differentially expressed lncRNAs was identified as candidate targets for directed therapy; although LINC01183 was not individually detailed, its inclusion among these transcripts suggests that it may contribute to the therapeutic response and could serve as a potential target in combination treatment strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In hepatocellular carcinoma, LINC01183 stands out as one of four methylation-regulated, differentially expressed lncRNAs that were integrated into a novel survival prognosis prediction model developed using TCGA data. This model not only outperforms traditional staging methods in predicting overall survival but also aids in classifying hepatoma cell lines for drug sensitivity evaluations, thereby offering potential guidance for the individualized treatment of HCC patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings underscore the emerging role of LINC01183 as a promising biomarker that may inform both prognostic assessment and targeted therapeutic interventions across different cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenyan Han, Rui Xiao, Chuanling Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selecting lncRNAs in gastric cancer cells for directed therapy with bioactive peptides and chemotherapy drugs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.20977"}], "href": "https://doi.org/10.18632/oncotarget.20977"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29156779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29156779"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Le-En Liao, Dan-Dan Hu, Yun Zheng "}, {"type": "b", "children": [{"type": "t", "text": "A Four-Methylated lncRNAs-Based Prognostic Signature for Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes11080908"}], "href": "https://doi.org/10.3390/genes11080908"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32784402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32784402"}]}]}]}