{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01184 is an emerging long non‑coding RNA that exhibits context‑dependent regulatory functions across multiple biological systems and disease states. In erythroid progenitor cells, for instance, genetic variation within a bidirectional promoter shared by LINC01184 and the nearby SLC12A2 gene has been implicated in the regulation of red blood cell traits, suggesting that disruption of this regulatory element can modulate transcription in these cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, LINC01184 is markedly upregulated and functions as an oncogenic competing endogenous RNA; by binding to microRNA‑331, it enhances the expression of HER2 and the activation of downstream phosphorylated Akt and ERK1/2 signaling, thereby promoting cell proliferation and invasion while inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, LINC01184 has been incorporated into immune‑related prognostic signatures—in neuroblastoma and thyroid cancer—where its expression correlates with disease stage and adverse outcomes, highlighting its potential utility as a biomarker for disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additional findings have reported altered expression of LINC01184 in the blood of patients with ischemic stroke, suggesting its involvement in pathological stress responses"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and its inclusion in a tumor‑infiltrating B‑lymphocyte lncRNA signature further indicates a role in mediating immune cell infiltration in the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chani J Hodonsky, Deepti Jain, Ursula M Schick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1006760"}], "href": "https://doi.org/10.1371/journal.pgen.1006760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28453575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28453575"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan-Xia Sui, Dong-Li Zhao, Yan Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Role, Function, and Mechanism of Long Intergenic Noncoding RNA1184 (linc01184) in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/8897906"}], "href": "https://doi.org/10.1155/2021/8897906"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33564344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33564344"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaodan Zhong, Ying Tao, Jian Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic Signature of Immune Genes and Immune-Related LncRNAs in Neuroblastoma: A Study Based on GEO and TARGET Datasets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.631546"}], "href": "https://doi.org/10.3389/fonc.2021.631546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33767996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33767996"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zheng Li, Hui Wang, Xia Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction and Validation of an Immune-Related lncRNA Prognosis Model for Thyroid Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comb Chem High Throughput Screen (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1386207325666220223123917"}], "href": "https://doi.org/10.2174/1386207325666220223123917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35209814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35209814"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wenzhen He, Duncan Wei, De Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered Long Non-Coding RNA Transcriptomic Profiles in Ischemic Stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Gene Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/hum.2017.064"}], "href": "https://doi.org/10.1089/hum.2017.064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29284304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29284304"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Meng Zhou, Zicheng Zhang, Siqi Bao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Computational recognition of lncRNA signature of tumor-infiltrating B lymphocytes with potential implications in prognosis and immunotherapy of bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brief Bioinform (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/bib/bbaa047"}], "href": "https://doi.org/10.1093/bib/bbaa047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32382761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32382761"}]}]}]}