{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01186 appears to function as a tumor‐suppressive long noncoding RNA in multiple cancer types. In papillary thyroid carcinoma, LINC01186 is significantly downregulated in tumor tissues compared with adjacent normal tissues, and lower expression is associated with lymph node metastasis. Overexpression of LINC01186 in PTC cell lines suppresses cell proliferation, colony formation, and invasion. Mechanistically, this overexpression modulates the LATS1/YAP signaling pathway by increasing LATS1 levels and reducing YAP1 expression, suggesting that LINC01186 may serve as a potential therapeutic target in thyroid carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In lung cancer, LINC01186 is also markedly downregulated. Its expression is reduced upon treatment with transforming growth factor‑β (TGF‑β1) in A549 cells, and bioinformatics analysis links LINC01186 to the epithelial‑mesenchymal transition (EMT) process. Downregulation of LINC01186 promotes cell migration and invasion, while its overexpression is able to inhibit these malignant behaviors. Notably, the expression of LINC01186 is regulated by SMAD3, further indicating that LINC01186 functions as a mediator of TGF‑β signaling, thereby influencing EMT markers and associated metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nanpeng Wang, Haisong Duan, Chen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The LINC01186 suppresses cell proliferation and invasion ability in papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2018.9349"}], "href": "https://doi.org/10.3892/ol.2018.9349"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30344719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30344719"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yajing Hao, Xinling Yang, Dongdong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01186, regulated by TGF-β/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2017.01.023"}], "href": "https://doi.org/10.1016/j.gene.2017.01.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28119085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28119085"}]}]}]}