{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01187 is a long non‐coding RNA whose expression pattern distinguishes specific renal cell carcinoma (RCC) subtypes. Global lncRNA profiling in RCC patient tissues demonstrated that LINC01187 is among a set of down‐regulated lncRNAs in tumor versus non-tumor tissues, supporting its potential as a biomarker for renal tumor biology monitoring."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, integrative transcriptomic analyses identified LINC01187 as a lineage-specific signature gene for chromophobe renal cell carcinoma (ChRCC); its robust and homogeneous expression was demonstrated in both primary and metastatic classic ChRCC, whereas other RCC subtypes consistently lacked unequivocal expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in normal kidney tissue, LINC01187 is localized to the distal nephron, specifically within intercalated cells, underscoring its value as an indicator of the cell-of-origin for these tumors. Collectively, these findings indicate that while LINC01187 may be downregulated in some RCC types, its selective and consistent expression in ChRCC establishes it as a promising diagnostic and potentially prognostic biomarker that reflects the underlying lineage and biology of renal tumors.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julia Bohosova, Marek Kasik, Adela Kubickova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24442"}], "href": "https://doi.org/10.1002/jcla.24442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35441392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35441392"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Stephanie L Skala, Xiaoming Wang, Yuping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Next-generation RNA Sequencing-based Biomarker Characterization of Chromophobe Renal Cell Carcinoma and Related Oncocytic Neoplasms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Urol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.eururo.2020.03.003"}], "href": "https://doi.org/10.1016/j.eururo.2020.03.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32299640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32299640"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Reza Alaghehbandan, Christopher G Przybycin, Virginie Verkarre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromophobe renal cell carcinoma: Novel molecular insights and clinicopathologic updates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian J Urol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajur.2021.11.010"}], "href": "https://doi.org/10.1016/j.ajur.2021.11.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35198391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35198391"}]}]}]}