{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNAs exhibit diverse functions in human diseases, and studies have begun to highlight context‐dependent roles for LINC01189. In patients with rheumatoid arthritis, screening of peripheral blood mononuclear cells revealed that LINC01189 is among several lncRNAs whose altered expression may serve as a diagnostic biomarker, correlating with clinical indexes and patient self‐perception (1). In contrast, investigations in hepatitis C virus–associated hepatocellular carcinoma indicate that LINC01189 is downregulated in tumor tissues and cell lines. Functional studies demonstrated that overexpression of LINC01189 suppresses cancer cell proliferation and chemoresistance to 5‐fluorouracil, at least in part through its interaction with and modulation of microRNA‐155‐5p, supporting a tumor‐suppressive role in the context of HCV‐linked liver cancer (2). Although other noncoding RNAs (such as miR-586 in breast cancer) are also implicated in oncogenic processes (3), the functional data concerning LINC01189 specifically underscore its potential utility both as a biomarker in inflammatory disease and as a tumor suppressor in HCV-associated carcinogenesis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", (3)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianting Wen, Jian Liu, Hui Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA expression profiles related to apoptosis and autophagy in peripheral blood mononuclear cells of patients with rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.12913"}], "href": "https://doi.org/10.1002/2211-5463.12913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32569434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32569434"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ying Yao, Fang Shu, Fang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01189 is associated with HCV-hepatocellular carcinoma and regulates cancer cell proliferation and chemoresistance through hsa-miR-155-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hepatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.aohep.2020.09.013"}], "href": "https://doi.org/10.1016/j.aohep.2020.09.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33059056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33059056"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Di Zhang, Xiaofeng Liu, Yun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01189-miR-586-ZEB1 feedback loop regulates breast cancer progression through Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2021.06.007"}], "href": "https://doi.org/10.1016/j.omtn.2021.06.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34513288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34513288"}]}]}]}