{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01191 is a long non‐coding RNA that has been identified as a component of a gene expression signature with potential prognostic utility in estrogen receptor–positive breast cancer. In particular, its expression—together with that of RP4‐639F20.1 and CTC‐429P9.3—correlates with distant metastasis–free survival, thereby classifying patients into distinct high‐risk and low‐risk groups for tamoxifen therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " These findings suggest that LINC01191 may serve as a valuable molecular marker to aid in the selection of patients likely to benefit from endocrine treatment. More broadly, research on long non‐coding RNAs in breast cancer underscores their emerging role as diagnostic and prognostic indicators, although further experimental validation is needed to clarify the underlying mechanisms of their action."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rong Liu, Rong Hu, Wei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA signature in predicting metastasis following tamoxifen treatment for ER-positive breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/pgs-2018-0032"}], "href": "https://doi.org/10.2217/pgs-2018-0032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29983093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29983093"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xu Bin, Yang Hongjian, Zhang Xiping, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Research progresses in roles of LncRNA and its relationships with breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-018-0674-0"}], "href": "https://doi.org/10.1186/s12935-018-0674-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30459529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30459529"}]}]}]}