{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence in inflammatory models indicates that key mediators such as stem cell factor (SCF) and eotaxin act in concert with leukotriene B₄ to orchestrate eosinophil recruitment in allergic settings. While these studies primarily focused on protein‐mediated events, emerging work suggests that noncoding elements like LINC01195 may regulate aspects of these inflammatory cascades, potentially fine‐tuning responses to low concentrations of these mediators during allergic inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of skeletal development and homeostasis, spatial expression studies have revealed that transcripts of stem cell growth factor (SCGF) localize predominantly to regions of active chondrogenesis and bone marrow niches, underscoring their importance in bone formation. In parallel, the osteogenic growth factor osteolectin (also known as Clec11a) has emerged as a pivotal regulator that mediates parathyroid hormone–induced activation of the Wnt signaling pathway, thereby promoting osteogenic differentiation and skeletal maintenance. These findings raise the possibility that LINC01195, by influencing the expression or activity of such key growth factors, could play a regulatory role in coordinating skeletal development and anabolic responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its implications in inflammation and skeletal biology, recent studies have also highlighted a protective role for Clec11a in metabolic tissues. In high‐fat diet models, Clec11a was shown to counteract lipotoxicity in pancreatic islets by promoting cell proliferation through activation of the Erk signaling pathway and by modulating genes linked to lipid metabolism. Such cytoprotective mechanisms suggest that LINC01195 might similarly contribute to safeguarding islet function under metabolic stress, adding an additional layer to its multifaceted regulatory potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A Klein, A Talvani, P M Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stem cell factor-induced leukotriene B4 production cooperates with eotaxin to mediate the recruitment of eosinophils during allergic pleurisy in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.167.1.524"}], "href": "https://doi.org/10.4049/jimmunol.167.1.524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11418691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11418691"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "A Hiraoka, K Yano Ki, N Kagami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hematol J (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.thj.6200118"}], "href": "https://doi.org/10.1038/sj.thj.6200118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11920266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11920266"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jingzhu Zhang, Adi Cohen, Bo Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2026176118"}], "href": "https://doi.org/10.1073/pnas.2026176118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34140410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34140410"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ruifeng Shi, Juan Hu, Wei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protective effects of Clec11a in islets against lipotoxicity via modulation of proliferation and lipid metabolism in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2019.111613"}], "href": "https://doi.org/10.1016/j.yexcr.2019.111613"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31494095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31494095"}]}]}]}